Pair Name	Plumbagin, rsTRAIL
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CASP8	hsa841
	Down-regulation	Expression	CFLAR	hsa8837
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	Kasumi-1	Childhood acute myeloid leukemia with maturation	Homo sapiens (Human)	CVCL_0589
In Vivo Model	Kasumi-1 cells were injected s.c. into the flanks of the mice (2.5×10⁶ in 2 ml) and tumors were allowed to develop for 18–30 days until they reached 50–100 mm3, then treatment was initiated.
Result	Our results suggest that both plumbagin and rsTRAIL could be used as a single agent or synergistical agents to induce apoptosis of leukemic Kasumi‑1 cells in vitro and in vivo.